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Chem Res Toxicol. 2021 Jan 12. doi: 10.1021/acs.chemrestox.0c00336. On-line forward of print.
ABSTRACT
Just lately developed computational fashions can estimate plasma, hepatic, and renal concentrations of commercial chemical substances in rats. Usually, the enter parameter values (i.e., the absorption charge fixed, quantity of systemic circulation, and hepatic intrinsic clearance) for simplified physiologically primarily based pharmacokinetic (PBPK) mannequin techniques are calculated to offer the very best match to measured or reported in vivo blood substance focus values in animals. The aim of the current examine was to estimate in silico these three enter pharmacokinetic parameters utilizing a machine studying algorithm utilized to a broad vary of chemical properties obtained from a number of cheminformatics software program instruments. These in silico estimated parameters had been then included into PBPK fashions for predicting inner exposures in rats. Following this strategy, simplified PBPK fashions had been arrange for 246 medication, meals parts, and industrial chemical substances with a broad vary of chemical constructions. We had beforehand generated PBPK fashions for 158 of those substances, whereas 88 for which focus collection information had been obtainable within the literature had been newly modeled. The values for the absorption charge fixed, quantity of systemic circulation, and hepatic intrinsic clearance could possibly be generated in silico by equations containing between 14 and 26 physicochemical properties. After digital oral dosing, the output focus values of the 246 compounds in plasma, liver, and kidney from rat PBPK fashions utilizing historically decided and in silico estimated enter parameters had been effectively correlated (r ≥ 0.83). In abstract, by utilizing PBPK fashions consisting of chemical receptor (intestine), metabolizing (liver), excreting (kidney), and central (primary) compartments with in silico-derived enter parameters, the ahead dosimetry of recent chemical substances might present the plasma/tissue concentrations of medicine and chemical substances after oral dosing, thereby facilitating estimates of hematotoxic, hepatotoxic, or nephrotoxic potential as part of danger evaluation.
PMID:33433197 | DOI:10.1021/acs.chemrestox.0c00336
